Main article: History of Syracuse, New Yorkįrench missionaries were the first Europeans to come to this area, arriving to work with and convert the Native Americans in the mid-17th century. Syracuse is home to Syracuse University, SUNY Upstate Medical University, SUNY ESF, and Le Moyne College. Its airport is the largest in the Central New York region. Today, Syracuse is at the intersection of Interstates 81 and 90. Historically, the city has functioned as a major crossroads over the last two centuries, first between the Erie Canal and its branch canals, then of the railway network. Syracuse was named after the classical Greek city Syracuse ( Siracusa in Italian), a city on the eastern coast of the Italian island of Sicily. Syracuse is also well-provided with convention sites, with a downtown convention complex. It is the economic and educational hub of Central New York, a region with over one million inhabitants. ![]() It is the fifth-most populous city in the state of New York following New York City, Buffalo, Yonkers, and Rochester.Īt the 2020 census, the city's population was 148,620 and its metropolitan area had a population of 662,057. Syracuse ( / ˈ s ɪr ə k j uː z, ˈ s ɛr-, - k j uː s/ SIRR-ə-kewz, SERR-, -kewss) is a city in and the county seat of Onondaga County, New York, United States.
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